Airbnb, Vacation Rentals in Santee, SC

Compare 202 available lakefront holiday vacation home properties, starts from $45

Navigate forward to interact with the calendar and select a date. Press the question mark key to get the keyboard shortcuts for changing dates.

Navigate backward to interact with the calendar and select a date. Press the question mark key to get the keyboard shortcuts for changing dates.

Find the best vacation rental

ACCOMMODATION TYPES

Save Up To 54%

Airbnb, Vacation rentals and hotel deals in Santee, SC

Americas Best Value Inn Saint George
Americas Best Value Inn Saint George
Americas Best Value Inn Saint George
Americas Best Value Inn Saint George
6.4 (24 reviews)
Americas Best Value Inn Saint George
Motel · 2 Guests · 1 Bedroom
$80 /night
View deal
Serenity at Santee
Serenity at Santee
Serenity at Santee
Serenity at Santee
9.6 (5 reviews)
Serenity at Santee
Condo · 2 Guests · 1 Bedroom
$250 /night*
View deal
Take a relaxing vacation in a quiet rural neighborhood-public boat dock nearby!
Take a relaxing vacation in a quiet rural neighborhood-public boat dock nearby!
Take a relaxing vacation in a quiet rural neighborhood-public boat dock nearby!
Take a relaxing vacation in a quiet rural neighborhood-public boat dock nearby!
4.0 (2 reviews)
Take a relaxing vacation in a quiet rural neighborhood-public boat dock nearby!
Holiday home · 2 Guests · 1 Bedroom
$150 /night*
View deal
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
6.8 (198 reviews)
Travelodge by Wyndham Santee
Hotel · 2 Guests · 1 Bedroom
$61 /night
View deal
Travelodge by Wyndham Orangeburg
Travelodge by Wyndham Orangeburg
Travelodge by Wyndham Orangeburg
Travelodge by Wyndham Orangeburg
Travelodge by Wyndham Orangeburg
Motel · 2 Guests · 1 Bedroom
$72 /night
View deal
Fairfield Inn & Suites Santee
Fairfield Inn & Suites Santee
Fairfield Inn & Suites Santee
Fairfield Inn & Suites Santee
9.7 (502 reviews)
Fairfield Inn & Suites Santee
Hotel · 2 Guests · 1 Bedroom
$164 /night
View deal
Family Friendly Lake Oasis
Family Friendly Lake Oasis
Family Friendly Lake Oasis
Family Friendly Lake Oasis
10 (9 reviews)
Family Friendly Lake Oasis
Holiday home · 2 Guests · 1 Bedroom
$241 /night*
View deal
Budget Inn
Budget Inn
Budget Inn
Budget Inn
Budget Inn
Motel · 2 Guests · 1 Bedroom
$70 /night
View deal
Knights Inn St. George
Knights Inn St. George
Knights Inn St. George
Knights Inn St. George
5.2 (47 reviews)
Knights Inn St. George
Motel · 2 Guests · 1 Bedroom
$60 /night
View deal
Super 8 by Wyndham Orangeburg Near I-26
Super 8 by Wyndham Orangeburg Near I-26
Super 8 by Wyndham Orangeburg Near I-26
Super 8 by Wyndham Orangeburg Near I-26
Super 8 by Wyndham Orangeburg Near I-26
Hotel · 2 Guests · 1 Bedroom
$73 /night
View deal
Baymont by Wyndham Santee
Baymont by Wyndham Santee
Baymont by Wyndham Santee
Baymont by Wyndham Santee
Baymont by Wyndham Santee
Motel · 2 Guests · 1 Bedroom
$86 /night
View deal
OYO Hotel Manning SC
OYO Hotel Manning SC
OYO Hotel Manning SC
OYO Hotel Manning SC
4.8 (81 reviews)
OYO Hotel Manning SC
Hotel · 2 Guests · 1 Bedroom
$42 /night
View deal
Baymont Inn & Suites
Baymont Inn & Suites
Baymont Inn & Suites
Baymont Inn & Suites
Baymont Inn & Suites
Motel · 2 Guests · 1 Bedroom
$90 /night
View deal
Sunset Inn Manning
Sunset Inn Manning
Sunset Inn Manning
Sunset Inn Manning
5.6 (9 reviews)
Sunset Inn Manning
Motel · 2 Guests · 1 Bedroom
$50 /night
View deal
Campers Paradise
Campers Paradise
Campers Paradise
Campers Paradise
9.2 (13 reviews)
Campers Paradise
RV park · 2 Guests · 1 Bedroom
$125 /night*
View deal
Comfort Inn & Suites Orangeburg
Comfort Inn & Suites Orangeburg
Comfort Inn & Suites Orangeburg
Comfort Inn & Suites Orangeburg
7.7 (80 reviews)
Comfort Inn & Suites Orangeburg
Hotel · 2 Guests · 1 Bedroom
$134 /night
View deal
Waterfront Condo 3BR/3BA- Lake Marion, Ballards Point II, Santee, SC
Waterfront Condo 3BR/3BA- Lake Marion, Ballards Point II, Santee, SC
Waterfront Condo 3BR/3BA- Lake Marion, Ballards Point II, Santee, SC
Waterfront Condo 3BR/3BA- Lake Marion, Ballards Point II, Santee, SC
9.6 (56 reviews)
Waterfront Condo 3BR/3BA- Lake Marion, Ballards Point II, Santee, SC
Condo · 2 Guests · 1 Bedroom
$170 /night*
View deal
House of the Rising Sun
House of the Rising Sun
House of the Rising Sun
House of the Rising Sun
9.4 (45 reviews)
House of the Rising Sun
Holiday home · 2 Guests · 1 Bedroom
$175 /night*
View deal
Econo Lodge Santee
Econo Lodge Santee
Econo Lodge Santee
Econo Lodge Santee
6.4 (42 reviews)
Econo Lodge Santee
Hotel · 2 Guests · 1 Bedroom
$73 /night
View deal
Quality Inn Manning I-95
Quality Inn Manning I-95
Quality Inn Manning I-95
Quality Inn Manning I-95
6.6 (440 reviews)
Quality Inn Manning I-95
Hotel · 2 Guests · 1 Bedroom
$77 /night
View deal
Search all

Vacation Destinations Near Santee, SC

Airbnb, Vacation House with Full Kitchen, and Other Rental Options in Santee, SC

Tom Charles Goat Island Fishing Retreat
Tom Charles Goat Island Fishing Retreat
Tom Charles Goat Island Fishing Retreat
Tom Charles Goat Island Fishing Retreat
Full Kitchen
9.6 (26 reviews)
Tom Charles Goat Island Fishing Retreat
Holiday home · 2 Guests · 1 Bedroom
$150 /night*
View deal
Vintage Family Lake House Lake Marion- NEW DOCK IN APRIL 2019
Vintage Family Lake House Lake Marion- NEW DOCK IN APRIL 2019
Vintage Family Lake House Lake Marion- NEW DOCK IN APRIL 2019
Vintage Family Lake House Lake Marion- NEW DOCK IN APRIL 2019
Full Kitchen
9.2 (17 reviews)
Vintage Family Lake House Lake Marion- NEW DOCK IN APRIL 2019
Holiday home · 2 Guests · 1 Bedroom
$150 /night*
View deal
Fabulous Location on southern shores of Lake Marion
Fabulous Location on southern shores of Lake Marion
Fabulous Location on southern shores of Lake Marion
Fabulous Location on southern shores of Lake Marion
Full Kitchen
8.6 (3 reviews)
Fabulous Location on southern shores of Lake Marion
Holiday home · 2 Guests · 1 Bedroom
$250 /night*
View deal
Search all
What Are The Well Liked Rental Amenities in Santee, SC?
Best Amenities in Santee, SC
+
There are in total of 15 rental amenities in Santee, shown above with the property numbers. In Santee, 91 rentals offer Parking Available, 89 rentals offer Internet or Wifi, 66 rentals offer Air Conditioning. So, if you need Parking Available during your vacation, use the Parking Available filter to compare these properties. Two amenities that are not typical are Hot Tub, Pets Friendly.
Which Price Range Is Most Typical in Santee, SC Area?
Vacation House & Hotel Rental Price Information in Santee, SC
+
The graph shows the percentages of vacation homes in each price bucket. Santee has the largest percentage (50.00%) of homes in $100 - $150 price range.
$0 to 50
$0 to 50
$50 to 100
$50 to 100
$100 to 150
$100 to 150
$150 to 200
$150 to 200
$200 to 250
$200 to 250
$250 to 300
$250 to 300
$300 to 350
$300 to 350
$350 to 400
$350 to 400
$400 to 450
$400 to 450
$450 to 500
$450 to 500
$500 +
$500 +
What Are The Most Liked Rental Accommodations in Santee, SC?
Most Picked Accommodations in Santee, SC
+
In Santee, 47.52% of listings are House, which is the most popular accommodation out of 8 total accommodation types. Avg price per night for House is around $199. And the most searched amenities for House accommodation is Hot Tub.The least popular accommodation in Santee is Recreational Vehicle rentals
How Many Accommodations Are Not Pets Friendly in Santee, SC?
Pets Allowed vs Not Allowed in Santee, SC
+
16.83% of vacation homes in Santee are pet friendly. Either you bring your loved pets on vacation or you have pet allergies, make sure to select the homes by applying the right filters.
Where Are The Good Trails in Santee, SC?
Must Visit Trails In Santee, SC
+
If you like outdoor activities, we highly recommend you to visit those famous trails: Coquina Trail, Palmetto Trail High Hills of Santee Passage, Palmetto Trail: Santee Passage, Francis Beidler Forest, Palmetto Trail: Lake Marion Passage, Limestone Nature Trail , Wrights Bluff Nature Trail, Santee Trail , Oak Pinolley Trail , Palmetto Trail Eutaw Springs Passage.
Where Are The Campgrounds in Santee, SC Area?
Most Visited Campgrounds In Santee, SC
+
For campgrounds in Santee, here are our recommendations: River Bottom Farms Family Campground, Point South / Yemassee KOA, Lake Aire RV Park & Campground, Oak Plantation Campground, Charleston KOA, Mount Pleasant / Charleston KOA, Congaree National Park Camping, Santee / Santee Lakes KOA, Swampfox Campground, Buck Hall Recreation Area.

Other Vacation Rentals Ideas

Airbnb, Vacation Hotel with Pool in Santee, SC

Comfort Inn & Suites Orangeburg
Comfort Inn & Suites Orangeburg
Comfort Inn & Suites Orangeburg
Comfort Inn & Suites Orangeburg
Pool
7.7 (80 reviews)
Comfort Inn & Suites Orangeburg
Hotel · 2 Guests · 1 Bedroom
$134 /night
View deal
Tru By Hilton Orangeburg
Tru By Hilton Orangeburg
Tru By Hilton Orangeburg
Tru By Hilton Orangeburg
Pool
Tru By Hilton Orangeburg
Hotel · 2 Guests · 1 Bedroom
$137 /night
View deal
Knights Inn St. George
Knights Inn St. George
Knights Inn St. George
Knights Inn St. George
Pool
5.2 (47 reviews)
Knights Inn St. George
Motel · 2 Guests · 1 Bedroom
$60 /night
View deal
Search all
* The displayed nightly rate may be estimated based on a future travel date. Narrow down your search with checkin and checkout dates to see the exact price.
See all offers